The HeyL-Aromatase Axis Promotes Cancer Stem Cell Properties by Endogenous Estrogen-Induced Autophagy in Castration-Resistant Prostate Cancer

Treatment of patients with castration-resistant prostate cancer (CRPC) remains a major clinical challenge. We previously showed that estrogenic effects contribute to CRPC progression and are primarily caused by the increased endogenous estradiol produced via highly expressed aromatase. However, the...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Qimei Lin, Jiasong Cao, Xiaoling Du, Kuo Yang, Yongmei Shen, Weishu Wang, Helmut Klocker, Jiandang Shi, Ju Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	CRPC HeyL aromatase autophagy prostate cancer stem cell
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.787953/full