Reversal of Alpha-Synuclein Fibrillization by Protein Disulfide Isomerase
Aggregates of α-synuclein contribute to the etiology of Parkinson’s Disease. Protein disulfide isomerase (PDI), a chaperone and oxidoreductase, blocks the aggregation of α-synuclein. An S-nitrosylated form of PDI that cannot function as a chaperone is associated with elevated levels of aggregated α-...
| Published in: | Frontiers in Cell and Developmental Biology |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-07-01
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| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2020.00726/full |