Early pharmacological blockade of the CXCL12-CXCR4 axis attenuates vertebral hypercalcification in a zebrafish model of pseudoxanthoma elasticum

Pseudoxanthoma elasticum (PXE), caused by pathogenic variants in ABCC6, is characterized by pathological ectopic calcification with poorly understood mechanisms and no effective therapies. To address this, we developed the first zebrafish model of human PXE by introducing the pathogenic ABCC6 point...

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Bibliographic Details

Published in:	Biochemistry and Biophysics Reports
Main Authors:	Jianjian Sun, Jichang Huang, Renjie Zhang, Shubin Zhang, Tao P. Zhong, Ping Zhu
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Subjects:	PXE ABCC6 Ectopic calcification Vitamin K1 CXCL12-CXCR4 axis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580825002912