Lysosomal TMEM106B interacts with galactosylceramidase to regulate myelin lipid metabolism

Abstract TMEM106B is an endolysosomal transmembrane protein not only associated with multiple neurological disorders including frontotemporal dementia, Alzheimer’s disease, and hypomyelinating leukodystrophy but also potentially involved in COVID-19. Additionally, recent studies have identified amyl...

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Bibliographic Details

Published in:	Communications Biology
Main Authors:	Hideyuki Takahashi, Azucena Perez-Canamas, Chris W. Lee, Hongping Ye, Xianlin Han, Stephen M. Strittmatter
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Online Access:	https://doi.org/10.1038/s42003-024-06810-5