In vivo and in vitro spermatogenesis in prepubertal mouse testes exposed to low gonadotoxic doses of cytarabine or Daunorubicin

Abstract The development of experimental models treated by chemotherapy is needed for elucidating the side effects of cancer treatments administered prior to puberty on male gonad function and the feasibility of restoring fertility from exposed testicular tissues. This study investigated for the fir...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Marion Delessard, Laura Moutard, Coline Charnay, Nathalie Rives, Ludovic Dumont, Magali Basille-Dugay, Aurélie Feraille, Christine Rondanino
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-04-01
Subjects:	Chemotherapy Cytarabine Daunorubicin Fertility restoration In vitro spermatogenesis Prepubertal mouse testis
Online Access:	https://doi.org/10.1038/s41598-025-98413-1