Membrane bridging by Munc13-1 is crucial for neurotransmitter release

Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C1, C2B, MUN and C2C domains of Munc13-1 (C1C2BMUNC2C) bridges the synaptic vesicle and plasma membranes through interactions involving the C2C domain and the C1-C2B region. Ho...

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Bibliographic Details

Published in:	eLife
Main Authors:	Bradley Quade, Marcial Camacho, Xiaowei Zhao, Marta Orlando, Thorsten Trimbuch, Junjie Xu, Wei Li, Daniela Nicastro, Christian Rosenmund, Josep Rizo
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-02-01
Subjects:	Munc13 neurotransmitter release synaptic vesicle fusion membrane bridging synaptic vesicle docking reconstitution
Online Access:	https://elifesciences.org/articles/42806