FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma

Aims and Hypothesis: This study aims to explore the specific molecular mechanism of folliculin (FLCN)-induced proliferation, migration, and invasion in clear cell renal cell carcinoma (ccRCC) and to investigate the relationship of FLCN and HIF2α. Folliculin was identified as a tumor suppressor gene....

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Bibliographic Details

Published in:	Frontiers in Molecular Biosciences
Main Authors:	Xuyang Zhao, Yadong Ma, Jie Cui, Haiyang Zhao, Lei Liu, Yueyuan Wang, Pengxiang Min, Lin Zhang, Yongchang Chen, Jun Du, Yujie Zhang, Luo Gu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-07-01
Subjects:	FLCN mTORC2 HIF2α nuclear import cell proliferation
Online Access:	https://www.frontiersin.org/article/10.3389/fmolb.2020.00121/full