Luciferase reporter mycobacteriophage (TM4::GeNL) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex

ABSTRACT Mycobacterium abscessus (MAB) infections are challenging to treat due to high-level resistance to anti-tuberculosis drugs, carbapenems, fluoroquinolones, and tetracyclines. Clarithromycin and amikacin are considered cornerstone drugs for MAB treatment due to their superior efficacy; however...

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Bibliographic Details

Published in:	Journal of Clinical Microbiology
Main Authors:	Saranathan Rajagopalan, Lahari Das, Donna J. Kohlerschmidt, Amy K. Rourke, Salika M. Shakir, Michelle H. Larsen, Max R. O’Donnell, Wendy A. Szymczak, Vincent E. Escuyer, Phyu M. Thwe, William R. Jacobs
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-09-01
Subjects:	Mycobacterium abscessus inducible macrolide resistance amikacin luciferase reporter mycobacteriophage erm(41)
Online Access:	https://journals.asm.org/doi/10.1128/jcm.00841-25