Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer

Labile iron, i.e. iron that is weakly bound and is relatively unrestricted in its redox activity, has been implicated in both the pathogenesis as well as treatment of cancer. Two cancer treatments where labile iron may contribute to their mechanism of action are pharmacological ascorbate and ionizin...

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Bibliographic Details

Published in:	Redox Biology
Main Authors:	Justin C. Moser, Malvika Rawal, Brett A. Wagner, Juan Du, Joseph J. Cullen, Garry R. Buettner
Format:	Article
Language:	English
Published:	Elsevier 2014-01-01
Subjects:	EPR Electron paramagnetic resonance Ionizing radiation Labile iron Ascorbate Ferritin
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231713000852