A modular model integrating metabolism, growth, and cell cycle predicts that fermentation is required to modulate cell size in yeast populations.

For unicellular organisms, the reproduction rate and growth are crucial fitness determinants and functional manifestations of the organism genotype. Using the budding yeast Saccharomyces cerevisiae as a model organism, we integrated metabolism, which provides energy and building blocks for growth, w...

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Bibliographic Details

Published in:	PLoS Computational Biology
Main Authors:	Marco Vanoni, Pasquale Palumbo, Federico Papa, Stefano Busti, Laura Gotti, Meike Wortel, Bas Teusink, Ivan Orlandi, Alex Pessina, Cristina Airoldi, Luca Brambilla, Marina Vai, Lilia Alberghina
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2025-07-01
Online Access:	https://doi.org/10.1371/journal.pcbi.1013296