Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

Abstract ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category. The pathogen Legionella pneumophila mediates atypical ubiqu...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-03-01
Online Access:	https://doi.org/10.1038/s41467-024-46649-2