On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity

ABSTRACT To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, lea...

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Bibliographic Details

Published in:	mBio
Main Authors:	Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan
Format:	Article
Language:	English
Published:	American Society for Microbiology 2024-06-01
Subjects:	malaria drug resistance aminopeptidase Plasmodium falciparum Plasmodium vivax
Online Access:	https://journals.asm.org/doi/10.1128/mbio.00966-24