Evolution of Mycobacterium tuberculosis drug resistance in the genomic era

Mycobacterium tuberculosis has acquired drug resistance to all drugs that have been used against it, including those only recently introduced into clinical practice. Compared to other bacteria, it has a well conserved genome due to its role as an obligate human pathogen that has adapted to a niche o...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Camus Nimmo, James Millard, Valwynne Faulkner, Johana Monteserin, Hannah Pugh, Eachan Oliver Johnson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Subjects:	TB acquired resistance within-host evolution clonal expansion compensatory mutations bedaquiline
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2022.954074/full