Fluorimetric Detection of Insulin Misfolding by Probes Derived from Functionalized Fluorene Frameworks

A group of functionalized fluorene derivatives that are structurally similar to the cellular prion protein ligand <i>N</i>,<i>N</i>′-(methylenedi-4,1-phenylene)bis [2-(1-pyrrolidinyl)acetamide] (GN8) have been synthesized. These compounds show remarkable native fluorescence d...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Álvaro Sarabia-Vallejo, Ana Molina, Mónica Martínez-Orts, Alice D’Onofrio, Matteo Staderini, Maria Laura Bolognesi, M. Antonia Martín, Ana I. Olives, J. Carlos Menéndez
Format:	Article
Language:	English
Published:	MDPI AG 2024-03-01
Subjects:	turn-on fluorescence fluorescence probes antioxidants insulin amyloid conformation insulin aggregates detection
Online Access:	https://www.mdpi.com/1420-3049/29/6/1196