Role of sphingosine 1-phosphate (S1P) in sepsis-associated intestinal injury

Sphingosine-1-phosphate (S1P) is a widespread lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PRs) to regulate downstream signaling pathways. Sepsis can cause intestinal injury and intestinal injury can aggravate sepsis. Thus, intestinal injury and sepsis are mutuall...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Gehui Sun, Bin Wang, Hongquan Zhu, Junming Ye, Xiaofeng Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Subjects:	S1P sepsis S1PRs signaling intestinal epithelial barrier immune
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1265398/full