Effect of hypoxia on the expression of genes that encode some IGFBP and CCN proteins in U87 glioma cells depends on IRE1 signaling

We have studied hypoxic regulation of the expression of different insulin-like growth factor binding­ protein genes in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1), a central mediator of endoplasmic reticulum stress, which controls cell proliferation and tumor gro...

Full description

Bibliographic Details

Published in:	The Ukrainian Biochemical Journal
Main Authors:	O. H. Minchenko, A. P. Kharkova, D. O. Minchenko, L. L. Karbovskyi
Format:	Article
Language:	English
Published:	National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2015-12-01
Subjects:	endoplasmic reticulum stress glioma cells hypoxia IGFBP10/CYR61 IGFBP6 IGFBP7 IGFBP9/NOV IRE1 inhibition mRNA expression WISP1 WISP2
Online Access:	http://ukrbiochemjournal.org/wp-content/uploads/2015/12/Minchenko_6_15.pdf