CXCR4 has a dual role in improving the efficacy of BCMA-redirected CAR-NK cells in multiple myeloma

Multiple myeloma (MM) is a plasma cell disease with a preferential bone marrow (BM) tropism. Enforced expression of tissue-specific chemokine receptors has been shown to successfully guide adoptively-transferred CAR NK cells towards the malignant milieu in solid cancers, but also to BM-resident AML...

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書誌詳細

出版年:	Frontiers in Immunology
主要な著者:	Michael W. Moles, Henry Erdlei, Lutz Menzel, Marialucia Massaro, Agnese Fiori, Mario Bunse, Moritz Schrimpf, Kerstin Gerlach, Venugopal Gudipati, John Reiser, Ketan Mathavan, Jodie P. Goodrich, Johannes B. Huppa, Jan Krönke, Bahram Valamehr, Uta E. Höpken, Armin Rehm
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2024-06-01
主題:	BCMA chimeric antigen receptor NK cells multiple myeloma chemokine receptor CXCR4 adoptive T cell therapy
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1383136/full