Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway

Chelerythrine (CHE) is a majorly harmful isoquinoline alkaloid ingredient in <i>Chelidonium majus</i> that could trigger potential hepatotoxicity, but the pivotal molecular mechanisms remain largely unknown. In the present study, CHE-induced cytotoxicity and the underlying toxic mechanis...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Yanling Lin, Qinzhi Zhang, Baofu Xie, Haiyang Jiang, Jianzhong Shen, Shusheng Tang, Chongshan Dai
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Subjects:	chelerythrine oxidative stress apoptosis mitochondrial apoptotic pathway Akt pathway
Online Access:	https://www.mdpi.com/2076-3921/11/9/1837