Switching Between Bicyclic and Linear Peptides — The Sulfhydryl-Specific Linker TPSMB Enables Reversible Cyclization of Peptides

Phage display-selected bicyclic peptides have already shown their great potential for the development as bioactive modulators of therapeutic targets. They can provide enhanced proteolytic stability and improved membrane permeability. Molecular design of new linker molecules has led to a variety of n...

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Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Christoph Ernst, Johannes Heidrich, Catharina Sessler, Julia Sindlinger, Dirk Schwarzer, Pierre Koch, Frank M. Boeckler
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-10-01
Subjects:	reversible peptide cyclisation sulfhydryl-specific linkers bicyclic peptides site-selective disulfide modification phage display
Online Access:	https://www.frontiersin.org/article/10.3389/fchem.2018.00484/full