MYC promotes fibroblast osteogenesis by regulating ALP and BMP2 to participate in ectopic ossification of ankylosing spondylitis

Abstract Background Ectopic ossification is an important cause of disability in patients with ankylosing spondylitis (AS). Whether fibroblasts can transdifferentiate into osteoblasts and contribute to ossification remains unknown. This study aims to investigate the role of stem cell transcription fa...

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Bibliographic Details

Published in:	Arthritis Research & Therapy
Main Authors:	Qianmei Jin, Yaoyang Liu, Zhiguo Zhang, Xingzhu Wen, Ziqiang Chen, Haijun Tian, Zijian Kang, Xin Wu, Huji Xu
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	Ankylosing spondylitis Inflammation Ligaments Ectopic ossification MYC
Online Access:	https://doi.org/10.1186/s13075-023-03011-z