NETSseq reveals inflammatory and aging mechanisms in distinct cell types, driving cerebellar decline in ataxia telangiectasia

Ataxia–telangiectasia (A–T) is a rare, autosomal recessive, multisystem disorder caused by mutations in the Ataxia–Telangiectasia Mutated (ATM) gene and is characterized by a devastating and progressive neurological pathology. The cellular and molecular changes driving the neurological abnormalities...

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Published in:	Frontiers in Neuroscience
Main Authors:	Giuliano G. Stirparo, Xiao Xu, Toni Thompson, Keith Page, Jenna R. M. Harvey, David Cadwalladr, Jason Lawrence, Russell J. Burley, Joel Juvvanapudi, Megan Roberts, Daniel F. Barker, Victoria Mulligan, Chloe Sherlock, Marina Lizio, Louisa Christie, Mani Mudaliar, Steven Sheardown, Brad Margus, Craig Thompson, Louise Dickson, Nicola L. Brice, Mark B. Carlton, Justin A. C. Powell, Lee A. Dawson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	ataxia telangiectasia NETSseq neurodegeneration inflammation aging ATR pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2025.1636787/full