Beyond Single Nucleotide Polymorphisms: CYP3A5∗3∗6∗7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients

Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A5 (CYP3A5) isoenzymes and membrane transport by P-glycoprotein. Interpatient pharmacokinetic variability has been associated with genotypic variants for both CYP3A5 or ABCB1. Tacrolimus pharmaco...

全面介绍

书目详细资料

发表在:	Frontiers in Genetics
Main Authors:	Daniel A. Brazeau, Kristopher Attwood, Calvin J. Meaney, Gregory E. Wilding, Joseph D. Consiglio, Shirley S. Chang, Aijaz Gundroo, Rocco C. Venuto, Louise Cooper, Kathleen M. Tornatore
格式:	文件
语言:	英语
出版:	Frontiers Media S.A. 2020-08-01
主题:	renal transplantation immunosuppression CYP3A5 genotypes tacrolimus race tacrolimus pharmacokinetics
在线阅读:	https://www.frontiersin.org/article/10.3389/fgene.2020.00889/full