Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears

• 出版年: Molecular Metabolism
• 主要な著者: Robbert J. Van der Pijl, Weikang Ma, Christopher T.A. Lewis, Line Haar, Amalie Buhl, Gerrie P. Farman, Marcus Rhodehamel, Vivek P. Jani, O Lynne Nelson, Chengxin Zhang, Henk Granzier, Julien Ochala
• フォーマット: 論文
• 言語: 英語
• 出版事項: Elsevier 2025-02-01
• 主題: Hibernation; Heart; Myosin; Metabolism
• オンライン･アクセス: http://www.sciencedirect.com/science/article/pii/S2212877824002151
• ISSN: 2212-8778

Aim: The aim of the present study was to define whether cardiac myosin contributes to energy conservation in the heart of hibernating mammals. Methods: Thin cardiac strips were isolated from the left ventricles of active and hibernating grizzly bears; and subjected to loaded Mant-ATP chase assays, X-ray diffraction and proteomics. Main findings: Hibernating grizzly bears displayed an unusually high proportion of ATP-conserving super-relaxed cardiac myosin molecules that are likely due to altered levels of phosphorylation and rod region stability. Conclusions: Cardiac myosin depresses the heart's energetic demand during hibernation by modulating its function.