A neutrophil elastase inhibitor, sivelestat, attenuates sepsis-induced acute kidney injury by inhibiting oxidative stress

Background: Sivelestat, a selective inhibitor of neutrophil elastase (NE), can mitigate sepsis-related acute lung injury. However, the role of sivelestat in inhibiting oxidative stress and attenuating sepsis-related acute kidney injury (AKI) remains unclear. Here, we reported the effects of sivelest...

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Bibliographic Details

Published in:	Heliyon
Main Authors:	Wei Zhu, Yingwei Ou, Chunnian Wang, Rongcheng An, Junmei Lai, Ye Shen, Xiangming Ye, Haochu Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-04-01
Subjects:	Sepsis Acute kidney injury Oxidative stress Neutrophil elastase inhibitor Sivelestat
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405844024053970