MRGPRX2 antagonist GE1111 attenuated DNFB-induced atopic dermatitis in mice by reducing inflammatory cytokines and restoring skin integrity

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disorder characterised by itching, erythema, and epidermal barrier dysfunction. The pathogenesis of AD is complex and multifactorial; however,mast cell (MC) activation has been reported to be one of the crucial mechanisms in the patho...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Trevor K. Wong, Ye Gi Choi, Philip H. Li, Billy K. C. Chow, Mukesh Kumar
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	MRGPRX2 atopic dermatitis eczema allergy inflammation small molecule antagonist
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1406438/full