Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

Most bacteria use an indirect pathway to generate aminoacylated glutamine and/or asparagine tRNAs. Clinical isolates of Mycobacterium tuberculosis with increased rates of error in gene translation (mistranslation) involving the indirect tRNA-aminoacylation pathway have increased tolerance to the fir...

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Bibliographic Details

Published in:	eLife
Main Authors:	Swarnava Chaudhuri, Liping Li, Matthew Zimmerman, Yuemeng Chen, Yu-Xiang Chen, Melody N Toosky, Michelle Gardner, Miaomiao Pan, Yang-Yang Li, Qingwen Kawaji, Jun-Hao Zhu, Hong-Wei Su, Amanda J Martinot, Eric J Rubin, Veronique Anne Dartois, Babak Javid
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2018-08-01
Subjects:	Mycobacterium tuberculosis mistranslation persister antibiotic tolerance kasugamycin
Online Access:	https://elifesciences.org/articles/36782