A robust pipeline for high-content, high-throughput immunophenotyping reveals age- and genetics-dependent changes in blood leukocytes

Summary: High-dimensional flow cytometry is the gold standard to study the human immune system in large cohorts. However, large sample sizes increase inter-experimental variation because of technical and experimental inaccuracies introduced by batch variability. Our high-throughput sample processing...

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Bibliographic Details

Published in:	Cell Reports: Methods
Main Authors:	Thomas Liechti, Sofie Van Gassen, Margaret Beddall, Reid Ballard, Yaser Iftikhar, Renguang Du, Thiagarajan Venkataraman, David Novak, Massimo Mangino, Stephen Perfetto, H. Benjamin Larman, Tim Spector, Yvan Saeys, Mario Roederer
Format:	Article
Language:	English
Published:	Elsevier 2023-10-01
Subjects:	CP: Immunology CP: Systems biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2667237523002837