Management of hematological toxicities after BCMA-directed CAR-T cell therapy

Abstract The CAR-HEMATOTOX (CAR-HT) score can assess hematotoxicity risk, but its utility in guiding supportive care remains underexplored. We analyzed 224 multiple myeloma patients treated with BCMA-directed CAR-T therapy (2016–2024), stratified by CAR-HT score (low <2 vs high ≥2). We evaluated...

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Bibliographic Details

Published in:	Blood Cancer Journal
Main Authors:	Joselle Cook, Supriya Gupta, Nadine Abdallah, Matthew Rees, Christopher Graham, Lay She Ng, Radhika Bansal, Andre De Menezes Silva Corraes, Kristina Helms, Rahma Warsame, David Dingli, Wilson Gonsalves, Taxiarchis Kourelis, Morie Gertz, Suzanne Hayman, Nelson Leung, Prashant Kapoor, Lisa Hwa, Amie Fonder, Miriam Hobbs, Leif Bergsagel, Udit Yadav, Erin Wiedmeier-Nutor, Saurabh Chhabra, Rafael Fonseca, Sikander Ailawadhi, Ricardo Parrondo, Shaji Kumar, Yi Lin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2026-03-01
Online Access:	https://doi.org/10.1038/s41408-026-01455-5