Untargeted metabolomics reveals distinct biomarkers and metabolic alterations in familial and non-genetic hypercholesterolemia in Saudi patients

BackgroundFamilial hypercholesterolemia (FH) and non-genetic hypercholesterolemia (HC) are both associated with elevated low-density cholesterol (LDL-C) levels, which increase the risk of cardiovascular disease. However, their underlying metabolic disturbances differ significantly. Untargeted metabo...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Hadiah Bassam Al Mahdi, Noor Ahmad Shaik, Zuhier Awan, Hussam Daghistani, Faisal Alandejani, Kawthar Saad Alghamdi, Ahmad A. Obaid, Rawabi Zahed, Reem Nabil Hassan, Sherif Edris, Babajan Banaganapalli, Abdulrahman Mujalli
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	familial hypercholesterolemia untargeted metabolomics KEGG database biomarkers cholic acid
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1670282/full