KIR/HLA pleiotropism: protection against both HIV and opportunistic infections.

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific...

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Bibliographic Details
Published in:PLoS Pathogens
Main Authors: Ying Qi, Maureen P Martin, Xiaojiang Gao, Lisa Jacobson, James J Goedert, Susan Buchbinder, Gregory D Kirk, Stephen J O'Brien, John Trowsdale, Mary Carrington
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-08-01
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.0020079&type=printable
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Summary:The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.
ISSN:1553-7366
1553-7374

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