Genome-wide antibiotic-CRISPRi profiling identifies LiaR activation as a strategy to resensitize fluoroquinolone-resistant Streptococcus pneumoniae

Abstract Streptococcus pneumoniae is a human pathogen that has become increasingly resistant to synthetic fluoroquinolone antibiotics that target bacterial topoisomerases. To identify pathways essential under fluoroquinolone stress and potential novel targets to revitalize use of this antibiotic cla...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Bevika Sewgoolam, Kin Ki Jim, Vincent de Bakker, Florian P. Bock, Paddy S. Gibson, Jan-Willem Veening
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Online Access:	https://doi.org/10.1038/s41467-025-61814-x