Unraveling the role of HIF2α in melanoma progression and epithelial–mesenchymal transition

Abstract Melanoma is a highly heterogeneous and aggressive malignancy. Hypoxia within the tumor microenvironment is closely associated with tumor progression. However, the role of hypoxia-inducible factor 2α (HIF2α), a key transcription factor, in melanoma remains poorly understood. In this study, t...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Zhao Han, Yanling Gao, Zhifeng Li, Zhao Liu, Jianzhong Zhang, Tingting Jing, Yanyan Xv, Guoying Miao, Xiaojing Li, Aijun Chen
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-07-01
Subjects:	HIF-2α Melanoma Tumor microenvironment Immune evasion EMT
Online Access:	https://doi.org/10.1038/s41598-025-02384-2