GDNF facilitates cognitive function recovery following neonatal surgical-induced learning and memory impairment via activation of the RET pathway and modulation of downstream effectors PKMζ and Kalirin in rats

Objective: The aim of this study is to elucidate the underlying mechanism through which glial cell line-derived neurotrophic factor (GDNF) improves cognitive deficits in adults resulting from neonatal surgical interventions. Methods: Newborn Sprague–Dawley rats, regardless of gender, were randomly a...

Full description

Bibliographic Details

Published in:	Brain Research Bulletin
Main Authors:	Yi Chen, Yu-Xin Zheng, Yi-Ze Li, Zhen Jia, Yuan Yuan
Format:	Article
Language:	English
Published:	Elsevier 2024-10-01
Subjects:	Learning and memory Glial cell line-derived neurotrophic factor Dendritic arborization spine density PKMζ Kalirin
Online Access:	http://www.sciencedirect.com/science/article/pii/S0361923024002120