How Are Adenosine and Adenosine A_2A Receptors Involved in the Pathophysiology of Amyotrophic Lateral Sclerosis?

Adenosine is extensively distributed in the central and peripheral nervous systems, where it plays a key role as a neuromodulator. It has long been implicated in the pathogenesis of progressive neurogenerative disorders such as Parkinson’s disease, and there is now growing interest in its role in am...

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Bibliographic Details

Published in:	Biomedicines
Main Authors:	Akihisa Mori, Brittany Cross, Shinichi Uchida, Jill Kerrick Walker, Robert Ristuccia
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Subjects:	adenosine adenosine A<sub>2A</sub> receptor amyotrophic lateral sclerosis
Online Access:	https://www.mdpi.com/2227-9059/9/8/1027