Is Glial Dysfunction the Key Pathogenesis of <i>LRRK2</i>-Linked Parkinson’s Disease?

Leucine rich-repeat kinase 2 (<i>LRRK2</i>) is the most well-known etiologic gene for familial Parkinson’s disease (PD). Its gene product is a large kinase with multiple functional domains that phosphorylates a subset of Rab small GTPases. However, studies of autopsy cases with LRRK2 mut...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Tatou Iseki, Yuzuru Imai, Nobutaka Hattori
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Subjects:	leucine rich-repeat kinase 2 Parkinson’s disease astrocytes microglia inflammation glial cells
Online Access:	https://www.mdpi.com/2218-273X/13/1/178