Apelin receptor inhibition in ischemia-reperfused mouse hearts protected by endogenous n-3 polyunsaturated fatty acids

Background: While the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on cardiac ischemia-reperfusion (IR) injury have been previously reported, limited data are available regarding how these fatty acids affect membrane receptors and their downstream signaling following IR injury. We a...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Shuang Zheng, Weijiang Tan, Xiang Li, Lijing Wang, Caiyi Zhu, W. Glen Pyle, Jianxin Chen, Jian Wu, Xuecong Ren, Honghua Chen, Yunzeng Zou, Peter H. Backx, Feng Hua Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	n-3 PUFA IR injury cardioprotection APLNR intracellular phosphorylation signaling
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1145413/full