In-Cell Testing of Zinc-Dependent Histone Deacetylase Inhibitors in the Presence of Class-Selective Fluorogenic Substrates: Potential and Limitations of the Method

The development of anticancer drugs based on zinc-dependent histone deacetylase inhibitors (HDACi) has acquired great practical significance over the past decade. The most important HDACi characteristics are selectivity and strength of inhibition since they determine the mechanisms of therapeutic ac...

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Bibliographic Details
Published in:Biomedicines
Main Authors: Alla Kleymenova, Anastasia Zemskaya, Sergey Kochetkov, Maxim Kozlov
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Subjects:
HDAC inhibitors
fluorogenic substrates
class selectivity
correctness/incorrectness of testing results
Online Access:https://www.mdpi.com/2227-9059/12/6/1203

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https://www.mdpi.com/2227-9059/12/6/1203

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