A critical residue in a conserved RBD epitope determines neutralization breadth of pan-sarbecovirus antibodies with recurring YYDRxxG motifs

ABSTRACT The emergence of pandemic coronaviruses remains a global health concern, highlighting the need for broadly neutralizing antibodies (bnAbs) that can target multiple sarbecoviruses. In this study, we isolated and characterized a novel antibody, pT1679, that demonstrates exceptional neutraliza...

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Bibliographic Details

Published in:	mBio
Main Authors:	Saskia C. Stein, George Ssebyatika, Tim Benecke, Luisa Ströh, Manoj K. Rajak, Benjamin Vollmer, Sarah Menz, Ja-Yun Waldmann, Sarah N. Tipp, Okechukwu Ochulor, Elisabeth Herold, Britta Schwarzloh, Doris Mutschall, Jasmin Zischke, Talia Schneider, Imke Hinrichs, Rainer Blasczyk, Hannah Kleine-Weber, Markus Hoffmann, Florian Klein, Franziska K. Kaiser, Mariana Gonzalez-Hernandez, Federico Armando, Malgorzata Ciurkiewicz, Georg Beythien, Stefan Pöhlmann, Wolfgang Baumgärtner, Kay Gruenewald, Albert Osterhaus, Thomas F. Schulz, Thomas Krey, Guido Hansen
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-09-01
Subjects:	neutralizing antibody neutralization escape receptor-binding domain sarbecovirus SARS-CoV-2
Online Access:	https://journals.asm.org/doi/10.1128/mbio.00606-25