Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents

A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins <b>3a–f</b> (isatin, <b>3a</b>, 6-chloroisatin, <b>3b</b>, 5-fluoroi...

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Bibliographic Details

Published in:	Molecules
Main Authors:	Abdullah Mohammed Al-Majid, M. Ali, Mohammad Shahidul Islam, Saeed Alshahrani, Abdullah Saleh Alamary, Sammer Yousuf, M. Iqbal Choudhary, Assem Barakat
Format:	Article
Language:	English
Published:	MDPI AG 2021-10-01
Subjects:	spirooxindole azomethine ylides [3+2] cycloaddition reaction anti-cancer activity
Online Access:	https://www.mdpi.com/1420-3049/26/20/6305