Use of hiPSC-Derived Cardiomyocytes to Rule Out Proarrhythmic Effects of Drugs: The Case of Hydroxychloroquine in COVID-19

In the early phases of the COVID-19 pandemic, drug repurposing was widely used to identify compounds that could improve the prognosis of symptomatic patients infected by SARS-CoV-2. Hydroxychloroquine (HCQ) was one of the first drugs used to treat COVID-19 due to its supposed capacity of inhibiting...

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Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Luca Sala, Vladislav Leonov, Manuela Mura, Federica Giannetti, Aleksandr Khudiakov, Alessandra Moretti, Lia Crotti, Massimiliano Gnecchi, Peter J. Schwartz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Subjects:	Long QT Syndrome COVID-19 hydroxychloroquine induced pluripotent stem cells safety pharmacology precision medicine
Online Access:	https://www.frontiersin.org/articles/10.3389/fphys.2021.730127/full