Mycobacterium tuberculosis Requires the Outer Membrane Lipid Phthiocerol Dimycocerosate for Starvation-Induced Antibiotic Tolerance

ABSTRACT Tolerance of Mycobacterium tuberculosis to antibiotics contributes to the long duration of tuberculosis (TB) treatment and the emergence of drug-resistant strains. M. tuberculosis drug tolerance is induced by nutrient restriction, but the genetic determinants that promote antibiotic toleran...

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Bibliographic Details
Published in:mSystems
Main Authors: Alisha M. Block, Sarah B. Namugenyi, Nagendra P. Palani, Alyssa M. Brokaw, Leanne Zhang, Kenneth B. Beckman, Anna D. Tischler
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Subjects:
PDIM
Mycobacterium tuberculosis
Tn-seq
antibiotic resistance
drug tolerance
membrane permeability
Online Access:https://journals.asm.org/doi/10.1128/msystems.00699-22

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https://journals.asm.org/doi/10.1128/msystems.00699-22

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