Lactate facilitated mitochondrial fission-derived ROS to promote pulmonary fibrosis via ERK/DRP-1 signaling

Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung diseases, which mainly existed in middle-aged and elderly people. The accumulation of reactive oxygen species (ROS) is a common characteristic of IPF. Previous research also shown that lactate levels c...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Zhiheng Sun, Zhihua Ji, Huiwen Meng, Wanyu He, Bin Li, Xiaoyue Pan, Yanlin Zhou, Guoying Yu
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	Idiopathic pulmonary fibrosis Reactive oxygen species DRP1 Lactate Mitochondrial fission
Online Access:	https://doi.org/10.1186/s12967-024-05289-2