Small ubiquitin-like modifiers inhibitors lower blood pressure via ERK5/KLF2-dependent upregulation of the eNOS/NO pathway

Small ubiquitin-like modifiers (SUMO)ylation is a dynamic and reversible post-translational modification playing pivotal roles in the regulation of cancer, diabetes, heart failure, and neurological diseases. However, whether SUMO inhibitors also have anti-hypertension effect remains yet to be explor...

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出版年:	Frigid Zone Medicine
主要な著者:	Tang Nannan, Li Jiatong, Wang Zhuo, Zuo Jinlu, Zhang Zifeng, Huang Di, Han Yannan, Chen Yuqing, Sun Yilin, Li Xiang, Mu Ruxue, Ma Qingxue, Zhang Jie, Wu Jiaying, Wang He, Zhao Hongxia, Dong Xingli, Wang Zhiguo, Liu Yu, Zhao Dan, Yang Baofeng
フォーマット:	論文
言語:	英語
出版事項:	De Gruyter 2025-01-01
主題:	hypertension sumo inhibitor erk5 sumoylation klf2
オンライン･アクセス:	https://doi.org/10.1515/fzm-2024-0020