N-glycosylation in the SERPIN domain of the C1-esterase inhibitor in hereditary angioedema

Hereditary angioedema is an autosomal dominant disorder caused by defects in C1-esterase inhibitor (C1-INH), resulting in poorly controlled activation of the kallikrein-kinin system and bradykinin overproduction. C1-INH is a heavily glycosylated protein in the serine protease inhibitor (SERPIN) fami...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Zhen Ren, John Bao, Shuangxia Zhao, Nicola Pozzi, H. James Wedner, John P. Atkinson
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2025-02-01
Subjects:	Immunology
Online Access:	https://doi.org/10.1172/jci.insight.185548