Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance.
Heme oxygenase (HO-1) mediates the enzymatic cleavage of heme, a molecule with proinflammatory and prooxidant properties. HO-1 activity deeply impacts host capacity to tolerate infection through reduction of tissue damage or affecting resistance, the ability of the host to control pathogen loads. In...
| Published in: | PLoS Pathogens |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-07-01
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| Online Access: | https://doi.org/10.1371/journal.ppat.1008599 |