The kinetics of uracil-N-glycosylase distribution inside replication foci

Abstract Mismatched nucleobase uracil is commonly repaired through the base excision repair initiated by DNA uracil glycosylases. The data presented in this study strongly indicate that the nuclear uracil-N-glycosylase activity and nuclear protein content in human cell lines is highest in the S phas...

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Bibliographic Details
Published in:Scientific Reports
Main Authors: Anna Ligasová, Ivo Frydrych, Barbora Piskláková, David Friedecký, Karel Koberna
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Online Access:https://doi.org/10.1038/s41598-024-84408-x