Michael acceptor molecules in natural products and their mechanism of action

Purpose: Michael receptor molecules derived from plants are biologically active due to electrophilic groups in their structure. They can target nucleophilic residues on disease-related proteins, with significant therapeutic effects and low toxicity for many diseases. They provide a good option for r...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Song-Ting Liang, Chu Chen, Rui-Xin Chen, Rui Li, Wen-Li Chen, Gui-Hua Jiang, Lei-Lei Du
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	Michael acceptor molecules bioactive plant components Keap1-Nrf2-ARE NF-κB covalent binding
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.1033003/full