Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Abstract Histone lysine methylation is thought to play a role in the pathogenesis of rheumatoid arthritis (RA). We previously reported aberrant expression of the gene encoding mixed-lineage leukemia 1 (MLL1), which catalyzes methylation of histone H3 lysine 4 (H3K4), in RA synovial fibroblasts (SFs)...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Keita Okamoto, Yasuto Araki, Yoshimi Aizaki, Shinya Tanaka, Yuho Kadono, Toshihide Mimura
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-05-01
Subjects:	Rheumatoid arthritis Synovial fibroblast Histone lysine methylation Cytokine Chemokine
Online Access:	https://doi.org/10.1038/s41598-024-60860-7