Low shear stress protects chondrocytes from IL-1β-induced apoptosis by activating ERK5/KLF4 signaling and negatively regulating miR-143-3p
Abstract Objective This study investigated the protective effects of low fluid shear stress (FSS ≤ 2 dyn/cm²) against interleukin-1β (IL-1β)-induced chondrocyte apoptosis and explored the underlying molecular mechanisms. Methods Chondrocytes were cultured under four conditions: control, IL-1β stimul...
| Published in: | Journal of Orthopaedic Surgery and Research |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-10-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-024-05140-w |