Mendelian randomization based on genome-wide association studies and expression quantitative trait loci, predicting gene targets for the complexity of osteoarthritis as well as the clinical prognosis of the condition

BackgroundOsteoarthritis (OA) entails a prevalent chronic ailment, marked by the widespread involvement of entire joints. Prolonged low-grade synovial inflammation serves as the key instigator for a cascade of pathological alterations in the joints.ObjectiveThe study seeks to explore potential thera...

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Bibliographic Details

Published in:	Frontiers in Medicine
Main Authors:	Yiqun Yan, Junyan He, Zelin Xu, Chen Wang, Zhongyao Hu, Chun Zhang, Wendan Cheng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-06-01
Subjects:	Mendelian randomization eQTL osteoarthritis WGCNA RF LASSO
Online Access:	https://www.frontiersin.org/articles/10.3389/fmed.2024.1409439/full